Importance of parallel vectors and "hydrophobic collapse" of the aligned aromatic rings: discovery of a potent substance P antagonist

J Med Chem. 1994 Dec 9;37(25):4263-6. doi: 10.1021/jm00051a001.
No abstract available

MeSH terms

  • Chemical Phenomena
  • Chemistry, Physical
  • Humans
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Piperidines / chemistry*
  • Piperidines / metabolism
  • Receptors, Neurokinin-1 / metabolism
  • Structure-Activity Relationship
  • Substance P / antagonists & inhibitors*

Substances

  • Piperidines
  • Receptors, Neurokinin-1
  • 3-(2-methoxybenzylamino)-2-phenylpiperidine
  • Substance P